Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome

Light-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome (dCRY) alters the dCRY conformation to promote binding and degradation of the circadian clock protein Timeless (TIM). Specific peptide ligation with sortase A attaches a nitroxide spin-probe to the dCRY C-termin...

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Udgivet i:Commun Biol
Main Authors: Chandrasekaran, Siddarth, Schneps, Connor M., Dunleavy, Robert, Lin, Changfan, DeOliveira, Cristina C., Ganguly, Abir, Crane, Brian R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910608/
https://ncbi.nlm.nih.gov/pubmed/33637846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01766-2
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