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Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction

Cryptochromes (CRYs) entrain the circadian clocks of plants and animals to light. Irradiation of the Drosophila cryptochrome (dCRY) causes reduction of an oxidized flavin cofactor by a chain of conserved tryptophan (Trp) residues. However, it is unclear how redox chemistry within the Trp chain coupl...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lin, Changfan, Top, Deniz, Manahan, Craig C., Young, Michael W., Crane, Brian R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899454/
https://ncbi.nlm.nih.gov/pubmed/29581265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719376115
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