Circadian clock cryptochrome proteins regulate autoimmunity

The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations, serum antinuclear antibodies,...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Cao, Qi, Zhao, Xuan, Bai, Jingwen, Gery, Sigal, Sun, Haibo, Lin, De-Chen, Chen, Qi, Chen, Zhengshan, Mack, Lauren, Yang, Henry, Deng, Ruishu, Shi, Xianping, Chong, Ling-Wa, Cho, Han, Xie, Jianjun, Li, Quan-Zhen, Müschen, Markus, Atkins, Annette R., Liddle, Christopher, Yu, Ruth T., Alkan, Serhan, Said, Jonathan W., Zheng, Ye, Downes, Michael, Evans, Ronald M., Koeffler, H. Phillip
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703267/
https://ncbi.nlm.nih.gov/pubmed/29109286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619119114
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