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Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein

Cleavage of the amyloid precursor protein (APP) by γ-secretase is a crucial first step in the evolution of Alzheimer’s disease. To discover the cleavage mechanism, it is urgent to predict the structures of APP monomers and dimers in varying membrane environments. We determined the structures of the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dominguez, Laura, Foster, Leigh, Straub, John E., Thirumalai, D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018773/
https://ncbi.nlm.nih.gov/pubmed/27559086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606482113
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