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Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein
Cleavage of the amyloid precursor protein (APP) by γ-secretase is a crucial first step in the evolution of Alzheimer’s disease. To discover the cleavage mechanism, it is urgent to predict the structures of APP monomers and dimers in varying membrane environments. We determined the structures of the...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5018773/ https://ncbi.nlm.nih.gov/pubmed/27559086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606482113 |
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