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Transmembrane fragment structures of Amyloid Precursor Protein depend on membrane surface curvature
The amyloid β (Aβ) peptide associated with Alzheimer’s Disease results from processing of the amyloid precursor protein (APP) by secretases. Following cleavage of APP by β-secretase, a 99 amino acid C-terminal fragment of APP (C99) is produced consisting of a single transmembrane (TM) helix. Simulat...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3928069/ https://ncbi.nlm.nih.gov/pubmed/24364734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja410958j |
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