Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer

Somatic copy number amplification and gene overexpression are common features of many cancers. To determine the role of gene overexpression on chromosome instability (CIN), we performed genome-wide screens in the budding yeast for yeast genes that cause CIN when overexpressed, a phenotype we refer t...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Duffy, Supipi, Fam, Hok Khim, Wang, Yi Kan, Styles, Erin B., Kim, Jung-Hyun, Ang, J. Sidney, Singh, Tejomayee, Larionov, Vladimir, Shah, Sohrab P., Andrews, Brenda, Boerkoel, Cornelius F., Hieter, Philip
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018746/
https://ncbi.nlm.nih.gov/pubmed/27551064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611839113
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