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Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1α

Objective: To explore the efficacy of ursolic acid in sensitizing colon cancer cells to chemotherapy under hypoxia and its underlying mechanisms. Methods: Three colon cancer cell lines (RKO, LoVo, and SW480) were used as in vitro models. 5-Fluorouracil (5-FU) and oxaliplatin were used as chemotherap...

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Bibliographic Details
Published in:J Zhejiang Univ Sci B
Main Authors: Shan, Jian-zhen, Xuan, Yan-yan, Zhang, Qi, Huang, Jian-jin
Format: Artigo
Language:Inglês
Published: Zhejiang University Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018614/
https://ncbi.nlm.nih.gov/pubmed/27604859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B1600266
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