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ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis

Therapeutic targeting of ASCT2, a glutamine transporter that plays a major role in glutamine uptake in cancer cells, is challenging because ASCT2 also has a biological role in normal tissue. In this study, we report our novel finding that ASCT2 is physically associated in a molecular complex with ep...

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Библиографические подробности
Опубликовано в: :Cancer Lett
Главные авторы: Lu, Haiquan, Li, Xinqun, Lu, Yang, Qiu, Songbo, Fan, Zhen
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017913/
https://ncbi.nlm.nih.gov/pubmed/27450723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2016.07.020
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