m(1)A and m(1)G Potently Disrupt A-RNA Structure Due to the Intrinsic Instability of Hoogsteen Base Pairs

The B-DNA double helix can dynamically accommodate G–C and A–T base pairs in either Watson-Crick or Hoogsteen configurations. Here, we show that G–C(+) and A–U Hoogsteen base pairs are strongly disfavored in A-RNA. As a result, N(1)-methyl adenosine and N(1)-methyl guanosine, which occur in DNA as a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Zhou, Huiqing, Kimsey, Isaac J., Nikolova, Evgenia N., Sathyamoorthy, Bharathwaj, Grazioli, Gianmarc, McSally, James, Bai, Tianyu, Wunderlich, Christoph H., Kreutz, Christoph, Andricioaei, Ioan, Al-Hashimi, Hashim M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016226/
https://ncbi.nlm.nih.gov/pubmed/27478929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3270
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky