m(1)A and m(1)G Potently Disrupt A-RNA Structure Due to the Intrinsic Instability of Hoogsteen Base Pairs

The B-DNA double helix can dynamically accommodate G–C and A–T base pairs in either Watson-Crick or Hoogsteen configurations. Here, we show that G–C(+) and A–U Hoogsteen base pairs are strongly disfavored in A-RNA. As a result, N(1)-methyl adenosine and N(1)-methyl guanosine, which occur in DNA as a...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Zhou, Huiqing, Kimsey, Isaac J., Nikolova, Evgenia N., Sathyamoorthy, Bharathwaj, Grazioli, Gianmarc, McSally, James, Bai, Tianyu, Wunderlich, Christoph H., Kreutz, Christoph, Andricioaei, Ioan, Al-Hashimi, Hashim M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016226/
https://ncbi.nlm.nih.gov/pubmed/27478929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3270
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