Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects

Elucidating the causes of congenital heart defects is made difficult by the complex morphogenesis of the mammalian heart, which takes place early in development, involves contributions from multiple germ layers, and is controlled by many genes. Here, we use a conditional/invertible genetic strategy...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Santos, Rosaysela, Kawauchi, Shimako, Jacobs, Russell E., Lopez-Burks, Martha E., Choi, Hojae, Wikenheiser, Jamie, Hallgrimsson, Benedikt, Jamniczky, Heather A., Fraser, Scott E., Lander, Arthur D., Calof, Anne L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016002/
https://ncbi.nlm.nih.gov/pubmed/27606604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2000197
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