Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome

Cornelia de Lange syndrome (CdLS) is a genetic disorder linked to mutations in cohesin and its regulators. To date, it is unclear which function of cohesin is more relevant to the pathology of the syndrome. A mouse heterozygous for the gene encoding the cohesin loader Nipbl recapitulates many featur...

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Main Authors: Remeseiro, Silvia, Cuadrado, Ana, Kawauchi, Shimako, Calof, Anne L., Lander, Arthur D., Losada, Ana
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825806/
https://ncbi.nlm.nih.gov/pubmed/23920377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.07.020
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