The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome

BACKGROUND: Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIPBL loads cohesin onto chromatin. Cohesin mediates sister chromatid cohesion...

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Bibliografski detalji
Izdano u:Clin Epigenetics
Glavni autori: Newkirk, Daniel A., Chen, Yen-Yun, Chien, Richard, Zeng, Weihua, Biesinger, Jacob, Flowers, Ebony, Kawauchi, Shimako, Santos, Rosaysela, Calof, Anne L., Lander, Arthur D., Xie, Xiaohui, Yokomori, Kyoko
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574093/
https://ncbi.nlm.nih.gov/pubmed/28855971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0391-x
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