Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer

BACKGROUND: The androgen receptor splice variant-7 (AR-V7) has been implicated in the development of castration-resistant prostate cancer (CRPC) and resistance to abiraterone and enzalutamide. OBJECTIVE: To develop a validated assay for detection of AR-V7 protein in tumour tissue and determine its e...

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Bibliographische Detailangaben
Veröffentlicht in:Eur Urol
Hauptverfasser: Welti, Jonathan, Rodrigues, Daniel Nava, Sharp, Adam, Sun, Shihua, Lorente, David, Riisnaes, Ruth, Figueiredo, Ines, Zafeiriou, Zafeiris, Rescigno, Pasquale, de Bono, Johann S., Plymate, Stephen R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2016
Schlagworte:
Platinum Priority – Prostate Cancer
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015575/
https://ncbi.nlm.nih.gov/pubmed/27117751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2016.03.049
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