Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

Hereditary Parkinson’s disease is commonly caused by mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged mitochondria. PINK1 phosphorylates both Parkin and ubiquitin to stimulate ubiquitination of dozens of proteins on the surface of...

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Udgivet i:Sci Rep
Main Authors: Klosowiak, Julian L., Park, Sungjin, Smith, Kyle P., French, Michael E., Focia, Pamela J., Freymann, Douglas M., Rice, Sarah E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015425/
https://ncbi.nlm.nih.gov/pubmed/27605430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33019
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