Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis

BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney. We therefore tested the hypothesis that tubu...

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Foilsithe in:J Am Heart Assoc
Main Authors: Seccia, Teresa M., Caroccia, Brasilina, Gioco, Francesca, Piazza, Maria, Buccella, Valentina, Guidolin, Diego, Guerzoni, Eugenia, Montini, Barbara, Petrelli, Lucia, Pagnin, Elisa, Ravarotto, Verdiana, Belloni, Anna S., Calò, Lorenzo A., Rossi, Gian Paolo
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2016
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015413/
https://ncbi.nlm.nih.gov/pubmed/27444511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003888
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