Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis

BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney. We therefore tested the hypothesis that tubu...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Am Heart Assoc
Päätekijät: Seccia, Teresa M., Caroccia, Brasilina, Gioco, Francesca, Piazza, Maria, Buccella, Valentina, Guidolin, Diego, Guerzoni, Eugenia, Montini, Barbara, Petrelli, Lucia, Pagnin, Elisa, Ravarotto, Verdiana, Belloni, Anna S., Calò, Lorenzo A., Rossi, Gian Paolo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2016
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015413/
https://ncbi.nlm.nih.gov/pubmed/27444511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003888
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