Endothelin‐1 Drives Epithelial‐Mesenchymal Transition in Hypertensive Nephroangiosclerosis

BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney. We therefore tested the hypothesis that tubu...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Seccia, Teresa M., Caroccia, Brasilina, Gioco, Francesca, Piazza, Maria, Buccella, Valentina, Guidolin, Diego, Guerzoni, Eugenia, Montini, Barbara, Petrelli, Lucia, Pagnin, Elisa, Ravarotto, Verdiana, Belloni, Anna S., Calò, Lorenzo A., Rossi, Gian Paolo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015413/
https://ncbi.nlm.nih.gov/pubmed/27444511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003888
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