Glycogen Synthase Kinase 3β Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome

BACKGROUND: Inhibition of glycogen synthase kinase 3β (GSK‐3β) has been reported to be cardioprotective during stressful conditions. METHODS AND RESULTS: Pigs were fed a high‐fat diet for 4 weeks to develop metabolic syndrome, then underwent placement of an ameroid constrictor to their left circumfl...

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Publicat a:J Am Heart Assoc
Autors principals: Potz, Brittany A., Sabe, Ashraf A., Elmadhun, Nassrene Y., Clements, Richard T., Robich, Michael P., Sodha, Neel R., Sellke, Frank W.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015402/
https://ncbi.nlm.nih.gov/pubmed/27405812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003694
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