Calpain Inhibition Improves Collateral Dependent Perfusion in a Hypercholesterolemic Swine Model of Chronic Myocardial Ischemia

BACKGROUND: Calpain over-expression is implicated in aberrant angiogenesis. We hypothesized that calpain inhibition (CI, MDL28170) would improve collateral perfusion in a swine model with hypercholesterolemia and chronic myocardial ischemia. METHODS AND RESULTS: Yorkshire swine fed a high cholestero...

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Detalhes bibliográficos
Publicado no:J Thorac Cardiovasc Surg
Main Authors: Sabe, Ashraf A., Potz, Brittany A., Elmadhun, Nassrene Y., Liu, Yuhong, Feng, Jun, Abid, M. Ruhul, Abbott, Jinnette D, Senger, Donald R, Sellke, Frank W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690774/
https://ncbi.nlm.nih.gov/pubmed/26478238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2015.08.101
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