Calpain Inhibition Decreases Myocardial Fibrosis in Chronically Ischemic Hypercholesterolemic Swine

OBJECTIVES: Calpain activation during ischemia is known to play critical roles in myocardial remodeling. We hypothesize that calpain inhibition (CI) may serve to reverse and/or prevent fibrosis in chronically ischemic myocardium. METHODS: Yorkshire swine were fed a high cholesterol diet for 4 weeks...

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發表在:J Thorac Cardiovasc Surg
Main Authors: Potz, Brittany A., Sabe, Ashraf A., Sabe, Sharif A., Lawandy, Isabella J., Abid, M. Ruhul, Clements, Richard T., Sellke, Frank W.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529741/
https://ncbi.nlm.nih.gov/pubmed/32359903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2019.11.150
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