Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats

CG200745 is a novel inhibitor of histone deacetylases (HDACs), initially developed for treatment of various hematological and solid cancers. Because it is water-soluble, it can be administered orally. We hypothesized that the HDAC inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in d...

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Vydáno v:Korean J Physiol Pharmacol
Hlavní autoři: Lee, Eunjo, Song, Min-ji, Lee, Hae-Ahm, Kang, Seol-Hee, Kim, Mina, Yang, Eun Kyoung, Lee, Do Young, Ro, Seonggu, Cho, Joong Myung, Kim, Inkyeom
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Physiological Society and The Korean Society of Pharmacology 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014994/
https://ncbi.nlm.nih.gov/pubmed/27610034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2016.20.5.477
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