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The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity

The pneumococcal autolysin LytA is a key virulence factor involved in several important functions including DNA competence, immune evasion and biofilm formation. Here, we present the 1.05 Å crystal structure of the catalytic domain of LytA in complex with a synthetic cell-wall-based peptidoglycan (P...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Microbiol
Egile Nagusiak: Sandalova, Tatyana, Lee, Mijoon, Henriques-Normark, Birgitta, Hesek, Dusan, Mobashery, Shahriar, Mellroth, Peter, Achour, Adnane
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014641/
https://ncbi.nlm.nih.gov/pubmed/27273793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13435
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