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Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers

BACKGROUND: The incidence and outcomes for patients with colorectal cancer (CRC) varies by age. Younger patients tend to have sporadic cancers not detected by screening and worse survival. To understand if genetic differences exist between age cohorts we sought to characterize unique genetic alterat...

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Publicat a:Cancer
Autors principals: Kothari, Nishi, Teer, Jamie K., Abbott, Andrea M., Srikumar, Thejal, Zhang, Yonghong, Yoder, Sean J., Brohl, Andrew S., Kim, Richard, Reed, Damon R., Shibata, David
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014625/
https://ncbi.nlm.nih.gov/pubmed/27244218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30082
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