In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation

MiR-34a, an important tumor-suppressing microRNA, is downregulated in several types of cancer; loss of its expression has been linked with unfavorable clinical outcomes in non-small-cell lung cancer (NSCLC), among others. MiR-34a represses several key oncogenic proteins, and a synthetic mimic of miR...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Cortez, Maria Angelica, Valdecanas, David, Niknam, Sharareh, Peltier, Heidi J, Diao, Lixia, Giri, Uma, Komaki, Ritsuko, Calin, George A, Gomez, Daniel R, Chang, Joe Y, Heymach, John Victor, Bader, Andreas G, Welsh, James William
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014539/
https://ncbi.nlm.nih.gov/pubmed/26670277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.47
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