DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization

siRNA and microRNA are promising therapeutic agents, which are engaged in a natural mechanism called RNA interference that modulates gene expression posttranscriptionally. For intracellular delivery of such nucleic acid triggers, we use sequence-defined cationic polymers manufactured through solid p...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Heissig, Philipp, Klein, Philipp M., Hadwiger, Philipp, Wagner, Ernst
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014462/
https://ncbi.nlm.nih.gov/pubmed/26928236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.6
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