Conserved patterns hidden within group A Streptococcus M protein hypervariability are responsible for recognition of human C4b-binding protein

No vaccine exists against group A Streptococcus (GAS), a leading cause of worldwide morbidity and mortality. A severe hurdle is the hypervariability of its major antigen, the M protein, with >200 different M types known. Neutralizing antibodies typically recognize M protein hypervariable regions...

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Pubblicato in:Nat Microbiol
Autori principali: Buffalo, Cosmo Z., Bahn-Suh, Adrian J., Hirakis, Sophia P., Biswas, Tapan, Amaro, Rommie E., Nizet, Victor, Ghosh, Partho
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014329/
https://ncbi.nlm.nih.gov/pubmed/27595425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2016.155
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