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Molecular simulations reveal an unresolved conformation of the Type-IA Protein Kinase A regulatory subunit and suggests its role in the cAMP regulatory mechanism

We identify a previously unresolved, unrecognized, and highly stable conformation of the Protein Kinase A (PKA) regulatory subunit RIα. This conformation, which we refer to as the “Flipback” structure, bridges conflicting characteristics in the crystallographic structures and solution experiments of...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Hirakis, Sophia P., Malmstrom, Robert D., Amaro, Rommie E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751417/
https://ncbi.nlm.nih.gov/pubmed/28661131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00461
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