Carregant...

Molecular simulations reveal an unresolved conformation of the Type-IA Protein Kinase A regulatory subunit and suggests its role in the cAMP regulatory mechanism

We identify a previously unresolved, unrecognized, and highly stable conformation of the Protein Kinase A (PKA) regulatory subunit RIα. This conformation, which we refer to as the “Flipback” structure, bridges conflicting characteristics in the crystallographic structures and solution experiments of...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Biochemistry
Autors principals: Hirakis, Sophia P., Malmstrom, Robert D., Amaro, Rommie E.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751417/
https://ncbi.nlm.nih.gov/pubmed/28661131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00461
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!