ADAM8 as a drug target in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) has a grim prognosis with less than 5% survivors after 5 years. High expression levels of ADAM8, a metalloprotease-disintegrin, are correlated with poor clinical outcome. We show that ADAM8 expression is associated with increased migration and invasiveness of...

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Vydáno v:Nat Commun
Hlavní autoři: Schlomann, Uwe, Koller, Garrit, Conrad, Catharina, Ferdous, Taheera, Golfi, Panagiota, Garcia, Adolfo Molejon, Höfling, Sabrina, Parsons, Maddy, Costa, Patricia, Soper, Robin, Bossard, Maud, Hagemann, Thorsten, Roshani, Rozita, Sewald, Norbert, Ketchem, Randal R., Moss, Marcia L., Rasmussen, Fred H., Miller, Miles A., Lauffenburger, Douglas A., Tuveson, David A., Nimsky, Christopher, Bartsch, Jörg W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014123/
https://ncbi.nlm.nih.gov/pubmed/25629724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7175
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