Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf

Kremen 1 and 2 have been identified as co-receptors for Dickkopf (Dkk) proteins, hallmark secreted antagonists of canonical Wnt signaling. We present here three crystal structures of the ectodomain of human Kremen1 (KRM1(ECD)) at resolutions between 1.9 and 3.2 Å. KRM1(ECD) emerges as a rigid molecu...

Full description

Saved in:
Bibliographic Details
Published in:Structure
Main Authors: Zebisch, Matthias, Jackson, Verity A., Zhao, Yuguang, Jones, E. Yvonne
Format: Artigo
Language:Inglês
Published: Cell Press 2016
Subjects:
Short Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5014086/
https://ncbi.nlm.nih.gov/pubmed/27524201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.06.020
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items