Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses

BACKGROUND: Cigarette smoking (CS) is the main risk factor for the development of chronic obstructive pulmonary disease (COPD) and most COPD exacerbations are caused by respiratory infections including influenza. Influenza infections are more severe in smokers. The mechanism of the increased risk an...

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Bibliographic Details
Published in:	Respir Res
Main Authors:	Wu, Wenxin, Zhang, Wei, Booth, J. Leland, Hutchings, David C., Wang, Xiaoqiu, White, Vicky L., Youness, Houssein, Cross, Cory D., Zou, Ming-Hui, Burian, Dennis, Metcalf, Jordan P.
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2016
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5013564/ https://ncbi.nlm.nih.gov/pubmed/27604339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0428-2
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Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses

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