Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine

Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States F...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Biomed Res Int
Autori principali: Murata, Stephen, Zhang, Catherine, Finch, Nathan, Zhang, Kevin, Campo, Loredana, Breuer, Eun-Kyoung
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2016
Soggetti:
Review Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013223/
https://ncbi.nlm.nih.gov/pubmed/27642590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2346585
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