Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine

Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States F...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Murata, Stephen, Zhang, Catherine, Finch, Nathan, Zhang, Kevin, Campo, Loredana, Breuer, Eun-Kyoung
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013223/
https://ncbi.nlm.nih.gov/pubmed/27642590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2346585
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