Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine

Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States F...

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Sparad:
Bibliografiska uppgifter
I publikationen:Biomed Res Int
Huvudupphovsmän: Murata, Stephen, Zhang, Catherine, Finch, Nathan, Zhang, Kevin, Campo, Loredana, Breuer, Eun-Kyoung
Materialtyp: Artigo
Språk:Inglês
Publicerad: Hindawi Publishing Corporation 2016
Ämnen:
Review Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013223/
https://ncbi.nlm.nih.gov/pubmed/27642590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2346585
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