Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

OBJECTIVES: Examine whether osteoarthritis (OA) progression can be delayed by halofuginone in anterior cruciate ligament transection (ACLT) rodent models. METHODS: 3-month-old male C57BL/6J (wild type; WT) mice and Lewis rats were randomised to sham-operated, ACLT-operated, treated with vehicle, or...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Cui, Zhuang, Crane, Janet, Xie, Hui, Jin, Xin, Zhen, Gehua, Li, Changjun, Xie, Liang, Wang, Long, Bian, Qin, Qiu, Tao, Wan, Mei, Xie, Min, Ding, Sheng, Yu, Bin, Cao, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013081/
https://ncbi.nlm.nih.gov/pubmed/26470720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-207923
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