Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis

Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for osteoarthritis due to limited understanding of osteoarthritis pathogenesis. We show that TGF–β1 is activated in the subchondral bone in response to altered mechanical loading in an anterio...

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Main Authors: Zhen, Gehua, Wen, Chunyi, Jia, Xiaofeng, Li, Yu, Crane, Janet L., Mears, Simon C., Askin, Frederic B., Frassica, Frank J., Chang, Weizhong, Yao, Jie, Nayfeh, Tariq, Johnson, Carl, Artemov, Dmitri, Chen, Qianming, Zhao, Zhihe, Zhou, Xuedong, Cosgarea, Andrew, Carrino, John, Riley, Lee, Sponseller, Paul, Wan, Mei, Lu, William Weijia, Cao, Xu
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676689/
https://ncbi.nlm.nih.gov/pubmed/23685840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3143
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