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Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model

Small interfering RNA (siRNA) is effective in silencing critical molecular pathways in cancer. The use of this tool as a treatment modality is limited by lack of an intelligent carrier system to enhance the preferential delivery of this molecule to specific targets in vivo. In the present study, the...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Principais autores: Perepelyuk, Maryna, Thangavel, Chellappagounder, Liu, Yi, Den, Robert B, Lu, Bo, Snook, Adam E, Shoyele, Sunday A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012553/
https://ncbi.nlm.nih.gov/pubmed/26812654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.56
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