Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models

BACKGROUND: The present study focuses on biodistribution profile and pharmacokinetic parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for siRNA/cisplatin combination therapy of lung cancer. MATERIAL & METHODS: Mad2 siRNA was encapsulated in EGFR targeted and nontargeted (...

Full description

Saved in:
Bibliographic Details
Published in:Nanomedicine (Lond)
Main Authors: Nascimento, Ana Vanessa, Gattacceca, Florence, Singh, Amit, Bousbaa, Hassan, Ferreira, Domingos, Sarmento, Bruno, Amiji, Mansoor M
Format: Artigo
Language:Inglês
Published: Future Medicine Ltd 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910968/
https://ncbi.nlm.nih.gov/pubmed/26980454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.16.14
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items