Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model

Liver fibrosis is the final stage of liver diseases that lead to liver failure and cancer. While various diagnostic methods, including the use of serum marker, have been established, no standard therapy has been developed. The objective of this study was to assess the approach of overexpressing matr...

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Bibliografiske detaljer
Udgivet i:Mol Ther Nucleic Acids
Main Authors: Abe, Hiroyuki, Kamimura, Kenya, Kobayashi, Yuji, Ohtsuka, Masato, Miura, Hiromi, Ohashi, Riuko, Yokoo, Takeshi, Kanefuji, Tsutomu, Suda, Takeshi, Tsuchida, Masanori, Aoyagi, Yutaka, Zhang, Guisheng, Liu, Dexi, Terai, Shuji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012547/
https://ncbi.nlm.nih.gov/pubmed/26730813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.49
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