Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model

Liver fibrosis is the final stage of liver diseases that lead to liver failure and cancer. While various diagnostic methods, including the use of serum marker, have been established, no standard therapy has been developed. The objective of this study was to assess the approach of overexpressing matr...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Abe, Hiroyuki, Kamimura, Kenya, Kobayashi, Yuji, Ohtsuka, Masato, Miura, Hiromi, Ohashi, Riuko, Yokoo, Takeshi, Kanefuji, Tsutomu, Suda, Takeshi, Tsuchida, Masanori, Aoyagi, Yutaka, Zhang, Guisheng, Liu, Dexi, Terai, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012547/
https://ncbi.nlm.nih.gov/pubmed/26730813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.49
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