The Neuronal Nitric Oxide Synthase Inhibitor NANT Blocks Acetaminophen Toxicity and Protein Nitration in Freshly Isolated Hepatocytes

3-Nitrotyrosine (3NT) in liver proteins of mice treated with hepatotoxic doses of acetaminophen (APAP) has been postulated to be causative in toxicity. Nitration is by a reactive nitrogen species formed from nitric oxide (NO). The source of the NO is unclear. iNOS knockout mice were previously found...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Banerjee, Sudip, Melnyk, Stepan B., Krager, Kimberly J., Aykin-Burns, Nukhet, Letzig, Lynda G., James, Laura P., Hinson, Jack A
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012542/
https://ncbi.nlm.nih.gov/pubmed/26454079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.09.022
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