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The Neuronal Nitric Oxide Synthase Inhibitor NANT Blocks Acetaminophen Toxicity and Protein Nitration in Freshly Isolated Hepatocytes
3-Nitrotyrosine (3NT) in liver proteins of mice treated with hepatotoxic doses of acetaminophen (APAP) has been postulated to be causative in toxicity. Nitration is by a reactive nitrogen species formed from nitric oxide (NO). The source of the NO is unclear. iNOS knockout mice were previously found...
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| Pubblicato in: | Free Radic Biol Med |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5012542/ https://ncbi.nlm.nih.gov/pubmed/26454079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.09.022 |
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