Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes

The hepatotoxicity of acetaminophen (APAP) occurs by initial metabolism to N-acetyl-p-benzoquinone imine which depletes GSH and forms APAP-protein adducts. Subsequently, the reactive nitrogen species peroxynitrite is formed from nitric oxide (NO) and superoxide leading to 3-nitrotyrosine in proteins...

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Bibliographic Details
Published in:Toxicol Rep
Main Authors: Banerjee, Sudip, Melnyk, Stepan B., Krager, Kimberly J., Aykin-Burns, Nukhet, McCullough, Sandra S., James, Laura P., Hinson, Jack A.
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426116/
https://ncbi.nlm.nih.gov/pubmed/28503408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2017.02.005
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