Acetaminophen-Induced Hepatotoxicity and Protein Nitration in Neuronal Nitric-Oxide Synthase Knockout Mice

In overdose acetaminophen (APAP) is hepatotoxic. Toxicity occurs by metabolism to N-acetyl-p-benzoquinone imine, which depletes GSH and covalently binds to proteins followed by protein nitration. Nitration can occur via the strong oxidant and nitrating agent peroxynitrite, formed from superoxide and...

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Autores principales: Agarwal, Rakhee, Hennings, Leah, Rafferty, Tonya M., Letzig, Lynda G., McCullough, Sandra, James, Laura P., MacMillan-Crow, Lee Ann, Hinson, Jack A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2012
Materias:
Toxicology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251022/
https://ncbi.nlm.nih.gov/pubmed/22001257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.184192
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