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Discriminating agonist and antagonist ligands of the nuclear receptors using 3D-pharmacophores
Nuclear receptors (NRs) constitute an important class of therapeutic targets. We evaluated the performance of 3D structure-based and ligand-based pharmacophore models in predicting the pharmacological profile of NRs ligands using the NRLiSt BDB database. We could generate selective pharmacophores fo...
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| Pubblicato in: | J Cheminform |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer International Publishing
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5011875/ https://ncbi.nlm.nih.gov/pubmed/27602059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-016-0154-2 |
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