The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

Clostridium difficile is the most common hospital acquired pathogen in the United States, and infection is in many cases fatal. Toxins A and B are its major virulence factors, but increasingly a third toxin may be present, known as C. difficile transferase (CDT). An ADP-ribosyltransferase that cause...

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Udgivet i:Nat Microbiol
Main Authors: Cowardin, Carrie A., Buonomo, Erica L., Saleh, Mahmoud M., Wilson, Madeline G., Burgess, Stacey L., Kuehne, Sarah A., Schwan, Carsten, Eichhoff, Anna M., Koch-Nolte, Friedrich, Lyras, Dena, Aktories, Klaus, Minton, Nigel P., Petri, William A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010011/
https://ncbi.nlm.nih.gov/pubmed/27573114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2016.108
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