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Perpetuating the homing endonuclease life cycle: identification of mutations that modulate and change I-TevI cleavage preference

Homing endonucleases are sequence-tolerant DNA endonucleases that act as mobile genetic elements. The ability of homing endonucleases to cleave substrates with multiple nucleotide substitutions suggests a high degree of adaptability in that changing or modulating cleavage preference would require re...

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Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Roy, Alexander C., Wilson, Geoffrey G., Edgell, David R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009752/
https://ncbi.nlm.nih.gov/pubmed/27387281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw614
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