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Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay

Previous high-throughput screens to identify mitochondrial toxicants used immortalized cell lines and focused on changes in mitochondrial membrane potential, which may not be sufficient and do not identify different types of mitochondrial dysfunction. Primary cultures of renal proximal tubule cells...

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Bibliografski detalji
Izdano u:Toxicol Sci
Glavni autori: Wills, Lauren P., Beeson, Gyda C., Hoover, Douglas B., Schnellmann, Rick G., Beeson, Craig C.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009421/
https://ncbi.nlm.nih.gov/pubmed/25926417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv085
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