Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding

The replacement of one Gly in the essential repeating tripeptide sequence of the type I collagen triple helix results in the dominant hereditary bone disorder osteogenesis imperfecta. The mechanism leading to pathology likely involves misfolding and autophagy, although it has been hypothesized that...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Yigit, Sezin, Yu, Hongtao, An, Bo, Hamaia, Samir, Farndale, Richard W., Kaplan, David L., Lin, Yu-Shan, Brodsky, Barbara
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Glycobiology and Extracellular Matrices
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009287/
https://ncbi.nlm.nih.gov/pubmed/27432884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.726182
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