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Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding
The replacement of one Gly in the essential repeating tripeptide sequence of the type I collagen triple helix results in the dominant hereditary bone disorder osteogenesis imperfecta. The mechanism leading to pathology likely involves misfolding and autophagy, although it has been hypothesized that...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5009287/ https://ncbi.nlm.nih.gov/pubmed/27432884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.726182 |
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