Collagen Gly missense mutations: Effect of residue identity on collagen structure and integrin binding

Gly missense mutations in type I collagen, which replace a conserved Gly in the repeating (Gly-Xaa-Yaa)(n) sequence with a larger residue, are known to cause Osteogenesis Imperfecta (OI). The clinical consequences of such mutations range from mild to lethal, with more serious clinical severity assoc...

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Publicado en:J Struct Biol
Autores principales: Qiu, Yimin, Mekkat, Arya, Yu, Hongtao, Yigit, Sezin, Hamaia, Samir, Farndale, Richard W., Kaplan, David L., Lin, Yu-Shan, Brodsky, Barbara
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089640/
https://ncbi.nlm.nih.gov/pubmed/29758270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2018.05.003
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