Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels

Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the potential relevance of ATX and LPA in HCC. Fi...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Enooku, Kenichiro, Uranbileg, Baasanjav, Ikeda, Hitoshi, Kurano, Makoto, Sato, Masaya, Kudo, Hiroki, Maki, Harufumi, Koike, Kazuhiko, Hasegawa, Kiyoshi, Kokudo, Norihiro, Yatomi, Yutaka
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008774/
https://ncbi.nlm.nih.gov/pubmed/27583415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161825
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