Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis

Lumbar spinal canal stenosis (LSS) or mechanical compression of dorsal root ganglion (DRG) is one of the causes of low back pain and neuropathic pain (NP). Lysophosphatidic acid (LPA) is a potent bioactive lipid mediator that is produced mainly from lysophosphatidylcholine (LPC) via autotaxin (ATX)...

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Publicado no:Sci Rep
Main Authors: Uranbileg, Baasanjav, Ito, Nobuko, Kurano, Makoto, Kano, Kuniyuki, Uchida, Kanji, Sumitani, Masahiko, Aoki, Junken, Yatomi, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889906/
https://ncbi.nlm.nih.gov/pubmed/33597645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83569-3
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